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Safety & Efficacy of Intravenous Tissue Plasminogen Activator & Heparin in Acute Middle Cerebral Artery Stroke Stroke 23:646-652, vonKummer,R.&Hacke,W., 1992 See this aricle in Pubmed Article Abstract Complete or partial reperfusion was observed in 11 patients(34%)90 minutes after the initiation of alteplase infusion and in 17 patients(53%)within 12-24 hours.Hemorrhagic infarction without clinical deterioration was detected by follow-up computed tomography in nine patients(28%).Fatal parenchymal hemorrhage occurred in three patients(9%)with huge middle cerebral artery infarcts.Serious hemorrhage from the puncture site occurred in two patients(6%).Good clinical outcome correlated with reperfusion(p<0.05)and the presence of grade 2 collateral blood flow(p<0. 01).Conclusions:When 100 mg of recombinant tissue plasminogen activator was given within the first 6 hours of acute stroke together with heparin the incidence of deleterious hemorrhage was<10%.Reperfusion and effective collateral blood flow seem to be two important factors associated with a small infarct volume and good clinical outcome.

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(click to filter results - removes previous filter) anticoagulant,treatment anticoagulant,treatment in CVD cerebrovascular accident cerebrovascular accident,acute management of cerebrovascular accident,thrombolytic agents in treatment fibrinolytic agents fibrinolytic agents,complications heparin middle cerebral artery,occlusion of tissue plasminogen activator,intravenous treatment of neurologic disorder

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